Lysosomes are membrane-bound organelles whose acidic lumen (pH 4.5–5.0) is required for degradation. This luminal acidity is ...

What do cells do when they are “hungry”? Eukaryotic cells cope with starving conditions by eating their own components, a process called autophagy. Aa Aa Aa Normally, when you are hungry you look for ...

In a rare disease called mucolipidosis type II, people's hearts and abdomens swell, and their bones grow malformed. A lysosomal storage disorder, mucolipidosis type II causes edema of the internal ...

For the first time, the pathway through which cells repair damaged lysosomes has been observed and described. Lysosomes are the recycling center of a cell, where molecular waste is degraded into the ...

Lysosomes are thought of as cellular organelles that play an important role in recycling proteins and maintaning cells by breaking down stuff that isn’t needed. But new research has found that ...

In humans, the SLC29A3 gene regulates the function of lysosomes to control waste recycling in cells such as macrophages (that engulf and destroy foreign bodies). This gene encodes for the lysosomal ...

Once thought of as having one simple job within cells, researchers continue to learn more about the importance of organelles called lysosomes. An organelle is a small structure in a cell that is ...

The rap sheet for β-CTF is growing longer. The C-terminal fragment, produced when β-secretase cleaves APP, binds to—and blocks assembly of—vacuolar ATPase, a proton pump that fuels acidification of ...

Therapeutic targeting of the AhR-Siglec-15 axis reveals potent efficacy against SHH medulloblastoma in preclinical models.

This article and associated images are based on a poster originally authored by Teresa Sorbo, Manuel Paina, Manuel Arcangeletti, Katja Blasi, Sara Martin, Donatella Bardelli, Paola Picardi, Fernanda ...

In a rare disease called mucolipidosis type II, people's hearts and abdomens swell, and their bones grow malformed. In a rare disease called mucolipidosis type II, people's hearts and abdomens swell, ...