For more than a decade, a class of drugs called BET inhibitors has been tested in cancer trials with high expectations. The ...

Cancer drugs known as BET inhibitors once looked like a breakthrough, but in real patients they’ve often fallen short. New ...

Anti-cancer drugs often fail, but a new discovery about how two key proteins interact with DNA is changing that, serving as a ...

Using rapid protein degradation, chemogenomics, and super‑resolution microscopy in mouse embryonic stem cells, the team dissected the distinct contributions of BRD2 and BRD4 to transcription.

When a gene is active, there is cellular machinery that transcribes the sequence of that gene from DNA into messenger RNA. This is a fundamental cellular process that is essential to the proper ...

The YABBY gene family comprises plant‐specific transcription factors that play pivotal roles in defining lateral organ polarity and promoting organogenesis in seed plants. These genes ...

Plants rely on gene regulators to grow, flower, reproduce, and survive drought, disease, and other environmental pressures.

Scientists at IOCB Prague are uncovering new details of gene transcription. They have identified a previously unknown molecular mechanism by which the transcription of genetic information from ...