Of all our organ systems, the gastrointestinal tract contains the highest levels of endogenous and exogenous proteases (also known as proteinases and peptidases); however, our understanding of their ...

Deep in our cells, a wide range of processes are occurring constantly. These cellular processes rely on enzymes to act as catalysts and set off a series of molecular interactions. There are still many ...

Chloroplast proteases are central to maintaining the functional integrity of the photosynthetic machinery. They regulate the degradation of damaged, misfolded, or obsolete proteins, thereby ensuring ...

This is a preview. Log in through your library . Abstract ADAMs are membrane-anchored proteases that regulate cell behavior by proteolytically modifying the cell surface and ECM. Like other ...

Molecular profiling of breast cancer via targeted tissue proteomics. Background: Estrogen receptors (ER) and invasive protease such as urokinase-type plasminogen activator (uPA), its inhibitor ...

A University of Alberta research team has identified a new drug target to treat harmful E. coli bacteria—which cause nearly 250,000 deaths a year from urinary tract infections (UTI) and are becoming ...

Ying Lin, Jacob M. Wozniak, Neil J. Grimsey, Sravan Girada, Anand Patwardhan, Olivia Molinar-Inglis, Thomas H. Smith, John D. Lapek, David J. Gonzalez, JoAnn Trejo Proceedings of the National Academy ...

Researchers have performed the first room temperature X-ray measurements on the SARS-CoV-2 main protease -- the enzyme that enables the virus to reproduce. It marks an important first step in the ...

α-Synuclein modulates neurite outgrowth as seen here in human cells, potentially suggesting involvement of the protein in learning processes of the brain. However, dysregulated α-Synuclein leads to ...