Figure 3: Various scaffolds utilized to engineer binders to Ras and their binding epitopes. Ras proteins are small GTPases that regulate cell growth and division. Mutations in Ras genes are associated ...
Tumors associated with oncogenic Ras in humans differ markedly from those in mice — which fail to form pancreatic, thyroid, or colon neoplasms — suggesting that the mechanism of Ras transformation may ...
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