Top1 releases torsional stress during DNA replication and transcription in actively proliferating cells 1. Owing to the high proliferative rate of cancer cells, Top1 inhibitors have long been ...

A topoisomerase enzyme discovered more than a decade ago in an archaeal microorganism turns out to be distinct, both structurally and mechanistically, from any other known topoisomerase. Only four ...

DNA topoisomerase I (Topo1) contributes to vital biological functions, but its regulation is not clearly understood. The BTBD1 protein was recently cloned on the basis of its interaction with the core ...

Randomized trial of vinorelbine compared with fluorouracil plus leucovorin in patients with stage IV non-small-cell lung cancer. Refractoriness to etoposide was defined as lack of response to ...

The COVID-19 pandemic has now entered its eighth month, but severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to spread in many parts of the world. Researchers are still ...

This fundamental role in cell life makes topoisomerase I an important target for cancer therapies: its inhibition leads to DNA strand breaks, preventing the replication of diseased cells. This ...

In Patients Younger Than Age 55 Years With Lymph Node–Negative Breast Cancer, Proliferation by Mitotic Activity Index Is Prognostically Superior to Adjuvant! Table 1. Comparison of Characteristics for ...

We have investigated the role of topoisomerase II (topo II) in mitotic chromosome assembly and organization in vitro using Xenopus egg extracts. When sperm chromatin was incubated with mitotic ...

For 40 years, etoposide has been a trusted chemotherapeutic for treating a variety of cancers. Etoposide succeeds by targeting Type IIA eukaryotic topoisomerases, enzymes - also known as topo IIs -- ...

In this paper, we show that hyperthermia suppresses the level of topoisomerase mediated single- and double-strand breaks induced by exposure to topoisomerase poisons. A new paper, High Temperature ...