eLife

Molidustat Targets a Synthetic Lethal Vulnerability in APC-Mutant Colorectal Cancer through GSTP1 and PHD2 Co-Inhibition

This important paper substantially advances our understanding of how Molidustat may work, beyond its canonical role, by identifying its therapeutic targets in cancer. This study presents a compelling ...
Scientific Research Publishing

Analytical Chemistry of New Psychoactive Substances: Methods, Applications and Future Prospects ()

New psychoactive substances (NPS) are a class of artificially designed and synthesized chemical substances designed to mimic the pharmacological effects of traditional drugs. They are characterized by ...
Scientific Research Publishing

The Effect of Club Goals on Innovative Behavior in Elementary School Mixed-Age Club Classes: The Mediating Role of Knowledge Sharing ()

Mixed-age Grouping, Club Goals, Knowledge Sharing, Innovative Behavior, Mediating Effect Yang, Y. , Liu, S. and Wang, J. (2026) The Effect of Club Goals on Innovative Behavior in Elementary School ...

Eldorado Gold Reminds Shareholders to Vote FOR the Share Issuance Resolution and Foran Mining Reminds Securityholders to Vote FOR the Arrangement Resolution

Eldorado Gold Corporation (TSX: ELD) (NYSE: EGO) ("Eldorado") reminds its shareholders to vote FOR the ordinary resolution approving the issuance of common shares of Eldorado (the "Share Issuance ...
ahajournals.org

Associations of Circulating ANGPTL3, C-Terminal Domain–Containing ANGPTL4, and ANGPTL3/8 and ANGPTL4/8 Complexes with LPL Activity, Diabetes, Inflammation, and Cardiovascular ...

ANGPTL3/4/8 (angiopoietin-like proteins 3, 4, and 8) are important regulators of LPL (lipoprotein lipase). ANGPTL8 forms complexes with ANGPTL3 and ANGPTL4. ANGPTL4/8 complex formation converts ...
ahajournals.org

Epidemiology and Cardiovascular Benefits of Physical Activity and Exercise

While humans evolved to perform routine endurance activity, recent secular trends in the United States and globally have resulted in a dramatic rise in the amount of time spent inactive in both ...
C&EN

Discovery and Characterization of a First-in-Class LIV1-TLR7/8 Immunomodulatory Conjugate with Robust Myeloid Activation and Antitumor Activity

Bristol Myers Squibb Research & Development, 700 Bay Road, Redwood City, California 94063, United States ...
CNBC

China's factory activity contracts less than expected in September — but shrinks for a fifth straight month

The official manufacturing purchasing managers' index came in at 49.8 in September, compared with 49.1 in August, 49.4 in July and 49.5 in June. The data slightly beat the 49.5 expected among ...
CNBC

U.S. economy grew at a 2.8% pace in the second quarter, much more than expected

Real gross domestic product increased at a 2.8% annualized pace in the second quarter, above the 2.1% forecast. The personal consumption expenditures price index, a key measure for the Fed, rose 2.6% ...
Frontiers

Examining the relationship between attitudes toward science and socioeconomic status among middle-class, midwestern middle school students

Previous research has uncovered disparities in children’s attitudes toward science based on gender, income, parenting, geographical location, and school resources, among other factors. However, less ...
C&EN

Pseudo-Luciferase Activity of the SARS-CoV-2 Spike Protein for Cypridina Luciferin

National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan Faculty of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, ...
Frontiers

Effects of the inclusion of physical activity in secondary education academic classes on educational indicators and health markers: rationale and methods of the ACTIVE CLASS study

Increasing physical activity (PA) levels and reducing sedentary behaviors in children and adolescents is a need, especially in schools. Active breaks and physically active learning are examples of two ...