Other than inheritance, PRSS1 pancreatitis has been considered clinically and pathologically indistinguishable from other etiologies of chronic pancreatitis. However, to date, the histologic …

Sep 11, 2020 · PRSS1 hereditary pancreatitis is a progressive disease. In early stages, fibrosis and loss of acinar and ductal tissue is mild and patchy while islets of Langerhans are relatively …

Jan 1, 2021 · The study was designed as a systematic review of the published literature related to the involvement of the PRSS1 gene in pancreatitis (including idiopathic chronic pancreatitis …

Mar 1, 2012 · The morphologic features and laboratory findings of PRSS1 -related hereditary pancreatitis are the same as those of other causes of hereditary (Table 2) and non-hereditary …

ic change (variant) was found in the PRSS1 gene. A positive PRSS1 variant is considered “pathogenic” or “likely pathogenic” becau. e it is associated w. th hereditary pancreatitis. What …

In summary, PRSS1 hereditary pancreatitis is characterized by progressive lipomatous atrophy of the pancreas. Dive into the research topics of 'The histopathology of PRSS1 hereditary …

May 18, 2022 · Here we define the genomics of PRSS1-PRSS2 and SPINK1 risk haplotypes at the population, organ, and single-cell level to better understand the mechanisms linking …

Genetically, HP is generally caused by gain-of-function mutations in the cationic trypsinogen gene (PRSS1), although rare kindreds have been identified with other known or unknown etiologies. …

Sep 23, 2025 · Hereditary pancreatitis (HP) is a rare genetic disorder of the pancreas. We report a case of a 20-year-old woman presenting with classic features of lean diabetes mellitus, …

Jun 13, 2013 · Therefore, genetic defects or specific polymorphisms in PRSS1 may influence the susceptibility and severity of pancreatitis. Since 1996, over 25 mutations in this gene have …